DOSAGE AND ADMINISTRATION Dosage In Patients With MDD, OCD, PD, PTSD, And SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. What is Zoloft? Zoloft is the brand name for the generic drug sertraline. Zoloft (sertraline) belongs to the class of antidepressant drugs and are conventionally described by their mechanism of action as selective serotonin reuptake inhibitors (SSRIS). The Zoloft dosage that doctors usually recommend for adults with depression or obsessive-compulsive disorder is 50 mg once a day. Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, healthcare providers often increase that dose to 50 mg daily. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Zoloft is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Zoloft is a medication that is licensed to treat depression, panic disorder, and other conditions. This eMedTV article provides an overview of this drug, including information about how it works, how to take it, and possible side effects. Dosage in Patients with MDD, OCD, PD, PTSD, and SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. Sertraline (Zoloft®) In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk.